Yian Yang, Anuraag Bukkuri, Dante Poe, Janet McLaughlin, Sihan Hao, Daniel D. Brown, Katarzyna M. Kedziora, Wayne Stallaert. Distinct p21 dynamics drive alternative routes to whole-genome duplication through a common CDK4/6-dependent polyploid G0 state. bioRxiv (2026) Preprint

Anuraag Bukkuri, Janet McLaughlin, Andrew W Duncan, Wayne Stallaert. Life History Enlightened Therapies: Cell Cycle Mapping to Identify Molecular Targets to Prevent Hepatocellular Carcinoma. Evolution, Medicine, and Public Health, eoag002 (2026) Full text

Nicholas A Pease, Jingyu Fan, Swapnil Keshari, Jered Stratton, Peter Gerges, Betsy Ann Varghese, Narayanan Nampoothiri VP, Christopher S McGinnis, Wenxi Zhang, Steven B Gierlack, Tanush Swaminathan, Akanksha Sachan, Godhev Manakkat Vijay, Luis Mena Hernandez, Zarifeh Heidari Rarani, Camila Macedo, Diana Metes, Ansuman T Satpathy, Abhinav K Jain, Nidhi Sahni, Wayne Stallaert, Jishnu Das, and Harinder Singh. Cell cycle-coupled transcriptional network orchestrates human B cell fate bifurcation. bioRxiv (2025) Preprint

Jolene S Ranek, Wayne Stallaert, J Justin Milner, Margaret Redick, Samuel C Wolff, Adriana S Beltran, Natalie Stanley, Jeremy E Purvis. DELVE: feature selection for preserving biological trajectories in single-cell data. Nature Communications. 15(1):2765 (2024) Full text

Osama Shiraz Shah, Azadeh Nasrazadani, Julia Foldi, Jennifer M Atkinson, Celina G Kleer, Priscilla F McAuliffe, Tyler J Johnston, Wayne Stallaert, Edaise M da Silva, Pier Selenica, Higinio Dopeso, Fresia Pareja, Diana Mandelker, Britta Weigelt, Jorge S Reis-Filho, Rohit Bhargava, Peter C Lucas, Adrian V Lee, Steffi Oesterreich. Spatial molecular profiling of mixed invasive ductal and lobular breast cancers reveals heterogeneity in intrinsic molecular subtypes, oncogenic signatures, and mutations. PNAS. 121(31): e2322068121 (2024) Full text

Kedziora KM and Stallaert W. Cell cycle mapping using multiplexed immunofluorescence.Methods Mol Biol. 2740:243-262 (2024) Preprint available here

Zikry TM, Wolff SC, Ranek JS, Davis HR, Naugle A, Luthra N, Whitman AA, Kedziora KM, Stallaert W, Kosorok MR, Spanheimer PM & Purvis JE. Cell cycle plasticity underlies fractional resistance to palbociclib in ER+/HER2- breast tumor cells.PNAS. 121(7): e2309261121 (2023) Full text

Stallaert W, Taylor SR, Kedziora KM, Johnson MS, Taylor CM, Sobon HS, Young CL, Limas JC, Cook JG & Purvis JE. The molecular architecture of cell cycle arrest.Molecular Systems Biology . 18:e11087 (2022) Full text

Stallaert W, Kedziora KM, Taylor CM, Zikry TM, Ranek JS, Sobon HS, Taylor SR, Young CL, Cook JG & Purvis JE. The structure of the human cell cycle.Cell Systems, 13(3): 230-240 (2022). Full text

Enrico TP, Stallaert W, Wick ET, Ngoi P, Rubin SM, Brown NG, Purvis JE & Emanuele MJ. Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2.eLife, 10:e70691 (2021) Full text

Brüggemann Y, Karajannis LS, Stanoev A, STALStallaertLAERT W & Bastiaens PIH. Growth factor– dependent ErbB vesicular dynamics couple receptor signaling to spatially and functionally distinct Erk pools.Science Signaling, 14(683)(2021)Full text

Stallaert W, Kedziora KM, Chao HX & Purvis JE. Bistable switches as integrators and actuators during cell cycle progression.FEBS letters, 593(20): 2805-2816(2019)Full text

Stallaert W, Brüggemann Y, Sabet O, Baak L & Bastiaens PIH. Contact inhibitory Eph signaling suppresses EGF-promoted cell migration by decoupling EGFR activity from vesicular recycling.Science Signaling, 11(541) (2018) Full text

Stanoev A, Mhamane A, Schuermann KC, Grecco HE, Stallaert W, Baumdick M, Bruggemann Y, Joshi MS, Roda-Navarro P, Fengler S, Stockert R, Rossmannek L, Luig J, Koseska A & Bastiaens PIH. Interdependence between EGFR and phosphatases spatially established by vesicular dynamics generates a growth factor sensing and responding network.Cell Systems, 7(3): 295-309 (2018) Full text

Schönegge A-M, Gallion J, Picard L-P, Wilkins AD, Le Gouill C, Audet M, Stallaert W, Lohse MJ, Kimmel M, Lichtarge O & Bouvier M. Evolutionary activation and structural basis of the allosteric switch controlling β2AR functional selectivity.Nature Communications, 87(1): 2169 (2017) Full text

Stallaert W, van der Westhuizen ET, Schönegge A, Plouffe B, Hogue M, Lukashova V, Inoue A, Ishida S, Aoki J, Le Gouill L, and Bouvier M. Purinergic receptor transactivation by the β2 adrenergic receptor increases intracellular Ca2+ in non-excitable cells.Molecular Pharmacology, 91(5):533-544 (2017) Full text

Thanawala VJ, Forkuo GS, Stallaert W, Leff P, Bouvier M and Bond R. Ligand bias prevents class equality among beta-blockers.Current Opinion Pharmacology, 16:50-57 (2014) Full text

Stallaert W, Dorn JF, van der Westhuizen E, Audet M, Bouvier M. Impedance Responses Reveal β2-Adrenergic Receptor Signaling Pluridimensionality and Allow Classification of Ligands with Distinct Signaling Profiles.PLoS One, 7(1): e29420 (2012) Full text

Stallaert W, Christopoulos A, and Bouvier M. Ligand functional selectivity and quantitative pharmacology at G protein-coupled receptors. Expert Opinion on Drug Discovery, 6(8):811-825 (2012)